- Original Article
- Anti-tumor effect of new compound, 127, through the induction of apoptosis
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Ki Hwan Baek, A Lum Han, Sae Ron Shin, Chun Mae Jin, Young Wook Yoon, Seung Taek Yu, Jong Duk Kim, Du Young Choi
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Clin Exp Pediatr. 2009;52(6):696-700. Published online June 15, 2009
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Purpose : We screened more than 350 compounds with an endoperoxide ring structure in search of an anti-leukemic drug and found that compound 127 (c-127) could induce significant cytotoxicity in HL-60 cells. In this study, we investigated the molecular mechanisms of compound 127-induced antitumor activity on HL-60 cells.
Methods : HL-60 cells were cultured in Rosewell Park Memorial Institute 1640... |
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- Case Report
- A case of dapsone syndrome
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Yoo Jong Won, Ok Lan Kim, Seung Taek Yu, Young Wook Yoon, Du Young Choi
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Clin Exp Pediatr. 2007;50(5):493-496. Published online May 15, 2007
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Diamino-diphenyl-sulfone (Dapsone) is widely used in the treatment of leprosy and a variety of blistering skin diseases. It sometimes has adverse side effects with common usual doses, such as skin, nervous system, gastrointestinal tract, liver, kidney and hematologic toxicity. One of these side effects is a rare but serious hypersensitivity reaction called dapsone syndrome, which occurs several weeks after the... |
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- Original Article
- The study on cytotoxicity of cytokines produced by the activated human NKT cells on neuroblastoma
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Jin Young Cho, Young Wook Yoon, Hyang Suk Yoon, Jong Duk Kim, Du Young Choi
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Clin Exp Pediatr. 2006;49(4):439-445. Published online April 15, 2006
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Purpose : α-Galactosylceramide (α-GalCer)-stimulated human Vα24 natural killer T (NKT) cells exert antitumor activity against some leukemia in a CD1d dependent and TCR-mediated manner, but could not kill CD1d - negative neuroblastoma (NB) cells. There are few reports about the direct antitumor effect of highly secreted cytokines by these cells on activation. In this study, using a cell-free supernatant (SPN)... |
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